. Author manuscript; available in PMC: 2016 May 5.

Published in final edited form as: Afr J Pharm Pharmacol. 2016 Mar;10(12):216–222. doi: 10.5897/AJPP2015.4488

Table 3.

Effect of M. scandens Ethanolic and aqueous extracts on seizure duration.

Treatment	Doses (mg/kg)	Seizure duration (min)	Seizure protection (%)	Level of significance
Distilled water		9.5 ± 2.5	37.5
MS WE	250	5.8 ± 2.0	75	P = 0.9999
MS WE	500	6.9 ± 2.5	75	P = 0.9999
MS WE	1000	2.4 ± 0.53	100	P = 0.2151
MS EE	250	3.3 ± 0.27	50	P = 0.5009
MS EE	500	5.4 ± 2.4	87.5	P = 0.9999
MS EE	1000	7.1 ± 1.5	100	P = 0.9999

Distilled water, Diazepam, M. scandens water extract (MS WE) and M. scandens ethanolic extract (MS EE) were administered orally 60 min before the injection of PTZ (60 mg/kg, i.p); values are the mean time ±S.E.M. for 8 rats. All the p-values were not significantly different compared to vehicle treated group, Two-way ANOVA followed by Bonferroni’s test Diazepam completely protected the animals from seizures.