. Author manuscript; available in PMC: 2016 May 5.

Published in final edited form as: Afr J Pharm Pharmacol. 2016 Mar;10(12):216–222. doi: 10.5897/AJPP2015.4488

Table 4.

Effect of M. scandens ethanolic and water extracts on seizure severity.

Treatment	Doses (mg/kg)	Seizure score	Seizure protection (%)	Level of significance
Distilled water	–	7.4 ± 0.32	37.5	–
MS WE	250	6.3 ± 0.45	75	P = 0.8785
MS WE	500	5.8 ± 0.77	75	P = 0.2583
MS WE	1000	6.0 ± 0.19	100	P= 0.0155^*
MS EE	250	6.8 ± 0.49	50	P = 0.9999
MS EE	500	6.3 ± 0.37	87.5	P = 0.2583
MS EE	1000	5.1 ± 0.30	100	P= 0.0155^*

Vehicle, Diazepam, M. scandens water extract (MS WE) and M. scandens ethanolic extract (MS EE) were administered orally 60 minutes before the injection of PTZ (60 mg/kg, i.p); values are the mean ± S.E.M. for 8 rats per group.

P < 0.05 significantly different compared to vehicle treated group, Two-way ANOVA followed by Sidak test Diazepam completely protected the animals from seizures.