. Author manuscript; available in PMC: 2016 May 5.

Published in final edited form as: Afr J Pharm Pharmacol. 2016 Mar;10(12):216–222. doi: 10.5897/AJPP2015.4488

Table 5.

Effect of M. scandens Ethanolic and aqueous extracts on the anxiogenic effects.

Treatment	Dose (mg/kg)	Time spent in (m)		Entries into

		Closed arm	Open arm	Closed arm	Open arm
Distilled water	–	2.04 ± 0.25	0.70 ± 0.18	3.4 ± 0.62	2.0 ± 0.50
MS WE	250	2.53 ± 0.47	2.95 ± 0.17^*	2.8 ± 0.55	3.1 ± 0.58
MS WE	500	4.07 ± 0.21^*	2.17 ± 0.46	1.8 ± 0.54	2.8 ± 0.58
MS WE	1000	3.12 ± 0.53	1.87 ± 0.53	2.3 ± 0.49	3.3 ± 0.81
MS EE	250	3.26 ± 0.18	1.73 ± 0.18	4.7 ± 0.77	6.0 ± 0.89^*a
MSEE	500	3.04 ± 0.40	1.71 ± 0.34	3.8± 0.47	4.0 ± 0.63
MSEE	1000	4.30 ± 0.18^*	0.93 ± 0.34	3.3 ± 0.36	3.0 ± 0.26
Diazepam	3	1.86 ± 0.38	3.20 ± 0.36^*	2.3 ± 0.62	2.6 ± 0.49

Values are expressed as mean ± SEM (n = 8). Two-way ANOVA followed by Bonferroni multiple comparisons test.

P < 0.05 when compared with control group.

^*a

P < 0.05 compares aqueous and ethanol extracts at 250 mg/kg.