Table 1.
Sensitivities of Scedosporium apiospermum isolate.
| Antifungal | First admission MICa (μg/ml) | Second admissions MICb (μg/ml) | Synergyb | MICb (μg/ml) | Interpretation |
|---|---|---|---|---|---|
| AMB | 2 | >2 | AMB+CAS | >2+>4 | Indifferent |
| MON | – | 0.5 | AMB+MICA | >2+>4 | Indifferent |
| ITC | >16 | – | |||
| VRC | 0.12 | 1 | AMB+POS | 2+4 | Indifferent |
| POS | 0.5 | >4 | AMB+VRC | 2+0.5 | Indifferent |
| MICA | – | 0.5 | MICA+TRB | 0.5+<0.015 | Indifferent |
| CAS | >8 | 1 | |||
| ANID | – | 4 | |||
| KTC | – | 1 | |||
| TRB | – | >2 | |||
| 5FC | >64 | – |
AMB, amphotericin B; MON, miconazole; ITC, itraconazole; 5FC, flucytosine; VRC, voriconazole; TRB, terbinafine; CAS, caspofungin; MICA, micafungin; POS, posaconazole; ANID, anidulafungin; KTC, ketoconazole
a
Obtained by CLSI adapted method based on breakpoints available for pathogenic yeasts, Wadsworth Center Laboratories, Albany NY.
b
Obtained by M38-A2 CLSI broth dilution antifungal susceptibility testing, University of Texas Health Science Center at San Antonio, South Texas reference laboratories.