Figure 4.

PG modulates survivin levels via regulating PTEN/Akt/GSK3β signaling in KB cells. KB cells were incubated with PG at the indicated concentrations (50 μg/ml if not indicated) for 48 h. (A) PG treatment results in increased PTEN mRNA levels in a dose-dependent manner. (B) PG treatment results in increased PTEN protein levels and the inhibition of Akt/GSK3β signaling. (C) The activation of Akt/GSK3β signaling abolishes the suppressive effect of PG on survivin expression. (D) The activation of Akt/GSK3β signaling abolishes the apoptosis-inducing effect of PG in KB cells. Mean±SD. n=3. ^*P<0.05, ^**P<0.01.