Table 1. PRO-CTCAE Item Formats^*.

Please think back over the past 7 days:	Example
Frequency (25 symptomatic AE terms): How OFTEN did you have __________? Never / Rarely / Occasionally / Frequently / Almost constantly	Vomiting
Severity (51 symptomatic AE terms): What was the SEVERITY of your __________ at its WORST? None / Mild / Moderate / Severe / Very severe	Pain
Interference (25 symptomatic AE terms): How much did __________ INTERFERE with your usual or daily activities? Not at all / A little bit / Somewhat / Quite a bit / Very much	Sudden urges to urinate
Presence (21 symptomatic AE terms): Did you have any __________? No / Yes	Unusual darkening of the skin
Amount (2 symptomatic AE terms): Did you have any __________? Not at all / A little bit / Somewhat / Quite a bit / Very much	Hair loss

Abbreviations: PRO-CTCAE, Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events; AE, adverse event

^*See Basch et al.¹⁵ for a complete listing of PRO-CTCAE items.