Table 3.

Comorbidities and Risk Factors Contributing to TAVI outcomes of Morbidity or Mortality

Risk Factor	HR/OR, 95% CI, P value	Trial Evaluating
STS score		Dewey et al.(79)
EuroSCORE		Nashef et al.(42)
SURTAVI score		Van Mieghem et al.(53)
BMI*	HR 0.96; CI,0.94 to 0.98; p<0.001	Kodali et al.(49)
Stroke history	HR 2.99; CI, 1.19 to 7.51; p=0.01	Makkar et al.(22)
COPD requiring oxygen	HR 1.69; CI, 1.05 to 2.73; p=0.03	Makkar et al.
Liver disease	HR 2.24; CI, 1.30 to 4.00; p= 0.006	Kodali et al.
Age**	OR 1.09, CI 1.03 to 16 p=0.005	Auffret et al.(80)
Frailty	HR 3.5; CI, 1.4 to 8.5; p<0.007	Green et al.(68)
Cognitive Impairment	OR 2.85 (1.32–6.17) 0.1	Stortecky et al.(67)
Malnutrition***	OR 1.30 (1.03–1.66) 0.03	Stortecky et al.
Trans-apical approach	OR 3.12; CI, 1.43 to 6.82; p=0.004	Van der Boon et al.(81)
PH ≥ 60 mm Hg	OR 7.56; CI, 2.58 to 22.17; p<0.001	Auffret et al.
Low-Flow	HR 1.48; CI, 1.13 to 1.97; p=0.005	Le Ven et al.(32)
Peri-procedural Cr	HR 1.06; CI, 1.00 to 1.13, p=0.04	Kodali et al.
Prior Vascular surgery	HR 1.85; CI, 1.01 to 3.39, p=0.05	Kodali et al.
Moderate to severe MR	HR 1.36 CI, 1.02 to 1.82, p=0.04	Kodali et al.

HR = Hazard Ratio, OR= Odds Ratio, CI= 95% Confidence Interval, BMI = Body Mass Index, COPD = Chronic Obstructive Pulmonary Disease, PH = Pulmonary Hypertension, Cr= Creatinine, MR = Mitral Regurgitation

^*Lower BMI seen to be protective; the hazard ratio represents an increase of 1

^**for each increase of 1 year

^***based on mini nutritional assessment (82)