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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: Cell Chem Biol. 2016 Jan 21;23(1):108–121. doi: 10.1016/j.chembiol.2015.12.007

Figure 4. O-Mannosyl Glycan of α-Dystroglycan.

Figure 4

The laminin-binding glycan of α-dystroglycan contains a core trisaccharide produced by POMT1/2, POMGnT2, and β3GalNT-2. The 6-OH position of mannose is phosphorylated by POMK, on which an unknown structure is added. β4GAT-1 makes an acceptor substrate for LARGE, which adds repeating GlcAβ(1–3)Xylα(1–3) units. The required roles of other associated enzymes such as FKTN are still unknown.