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. 2015 Aug 26;2(4):202–216. doi: 10.1002/reg2.39

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© 2015 The Authors. Regeneration published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Distribution of deviated nerve fibers in the wound epithelium of mice and Xenopus. (A) Illustrations show the surgeries that each limb was given. By this surgery, blastema formation is induced in Xenopus (B) (2 weeks after surgery) but not in mice (not shown). (C), (D) Immunohistochemistry for nerve fibers in the WE. Compared to the intact epidermis of each animal, fewer nerve fibers were found in the WE of mice (C) (6 days after surgery), whereas the WE in Xenopus is more innervated (D) (7 days after surgery). The arrowheads indicate the WE innervated by the deviated nerves. Scale bar 500 μm (applicable to C).