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. 2016 May 5;6:25457. doi: 10.1038/srep25457

Figure 1. Changes in the splenic tissue concentrations of 15 cytokines following systemic LPS challenge.

Figure 1

Cytokine concentrations were measured with the multiplex assay and comparisons made among the saline control (C) and 1, 4, and 24 h following systemic LPS injection. Data were analyzed with one-way ANOVA followed by Tukey’s post hoc procedure. All cytokines were categorized into one of groups A–F according to the patterns of time-dependent changes in the tissue concentration (Table 3). Graphs for the group A cytokines are indicated with a pink background, group B with yellow, group C with blue, group D with orange, and group F with white. Mean ± SEM. For CCL2, IL-1β, and LIF, n = 5 per experimental group and for the other 12 cytokines, n = 7 for saline control and n = 5 for each LPS treatment condition. **p < 0.01, *p < 0.05, and (*)0.05 ≤ p < 0.06, compared with the saline control; ##p < 0.01, #p < 0.05, and (#)0.05 ≤ p < 0.06, compared with 1 h after LPS injection;++p < 0.01 and +p < 0.05, compared with 4 h after LPS injection.