Figure 6. Increase in vimentin expression in the hippocampal parenchyma following systemic LPS challenge.

Immunohistochemistry revealed that vimentin expression was detected only around some blood vessels in the saline control (a) and was increased in the hippocampal parenchyma not only around the blood vessels, but also in astrocytic cytoplasmic processes not associated with blood vessels 4 and 24 h after LPS injection (b,c, respectively). The percentage of the vimentin-immunopositive area was increased significantly 4 and 24 h after LPS injection compared with the saline control (d). Scale bars 50 μm. **p < 0.01 and *p < 0.05, compared with the saline control.