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. 2016 Jan 6;3(1):26–38. doi: 10.1002/reg2.49

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© 2016 The Authors. Regeneration published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The process of joint regeneration in frogs. Left panel: Amputated frog forelimb after amputation at the elbow joint. Middle panel: At 3 weeks after amputation, the partial connection between the remaining joint cartilage and the regenerating spike cartilage is divided by a cavity between these apposing cartilages, and the interlocking structure is thereby reformed. Right panel: At 4 weeks after amputation, tenocytes are regenerated between the extremity of the remaining muscles and the regenerating cartilage.