Table 1.
Participant characteristics according to quintile of hepatocyte growth factor at Exam 1, The Multi-Ethnic Study of Atherosclerosis
| Quintile of Hepatocyte Growth Factor (HGF pg/mL) | |||||
|---|---|---|---|---|---|
| Quintile 1 (n=1079) | Quintile 2 (n=1079) | Quintile 3 (n=1079) | Quintile 4 (n=1079) | Quintile 5 (n=1079) | |
|
| |||||
| HGF (μg/L) | 61 ± 8 | 77 ± 4 | 89 ± 3 | 101 ± 5 | 130 ± 21 |
| Range | 29 – 71 | 71 – 83 | 83 – 95 | 95 – 111 | 111 – 275 |
| Age (years) | 58 ± 9 | 60 ± 10 | 62 ± 10 | 63 ± 10 | 66 ± 11 |
| Female (%) | 49 | 52 | 54 | 56 | 57 |
| Race (%) | |||||
| Non-Hispanic White | 49 | 43 | 40 | 41 | 41 |
| Chinese | 18 | 16 | 13 | 8 | 5 |
| African-American | 23 | 27 | 26 | 27 | 23 |
| Hispanic | 10 | 15 | 22 | 25 | 32 |
| Education (%) | |||||
| < High school (HS) | 9 | 12 | 17 | 19 | 21 |
| HS, some college | 41 | 44 | 45 | 48 | 53 |
| ≥ College degree | 50 | 44 | 38 | 32 | 25 |
| Smoking (%) | |||||
| Current use | 9 | 10 | 12 | 15 | 18 |
| Pack-years smoking | 9 ± 20 | 8 ± 16 | 10 ± 18 | 13 ± 24 | 14 ± 22 |
| Alcohol Use (%) | |||||
| Never | 18 | 20 | 19 | 20 | 19 |
| Former | 19 | 20 | 21 | 23 | 26 |
| Current; ≤ 1 drink daily | 51 | 49 | 50 | 46 | 47 |
| Current; > 1 drink daily | 12 | 11 | 9 | 11 | 8 |
| Physical activity (Mets) | 6300 ± 6212 | 6281 ± 5897 | 5763 ± 5709 | 5922 ± 6660 | 5168 ± 4960 |
| Systolic BP (mmHG) | 120 ± 19 | 123 ± 20 | 126 ± 21 | 128 ± 22 | 129 ± 21 |
| Diastolic BP (mmHG) | 72 ± 10 | 72 ± 10 | 72 ± 10 | 72 ± 10 | 71 ± 10 |
| BP-Lowering Medications (%) | 21 | 24 | 28 | 31 | 40 |
| BMI (kg/m2) | 26 ± 5 | 27 ± 5 | 28 ± 5 | 29 ± 5 | 30 ± 6 |
| Waist Circumference (cm) | 92 ± 13 | 95 ± 13 | 97 ± 14 | 99 ± 14 | 102 ± 14 |
| Fasting Glucose (mmol/L) | 4.8 ± 0.5 | 4.9 ± 0.6 | 5.0 ± 0.6 | 5.0 ± 0.6 | 5.1 ± 0.7 |
| Fasting Insulin (pmol/L) | 55.6 ± 27.8 | 62.5 ± 34.7 | 62.5 ± 34.7 | 69.5 ± 34.7 | 83.3 ± 48.6 |
| Total Cholesterol (mmol/L) | 5.0 ± 0.9 | 5.1 ± 0.9 | 5.1 ± 0.9 | 5.1 ± 0.9 | 5.0 ± 0.9 |
| LDL (mmol/L) | 3.0 ± 0.8 | 3.1 ± 0.8 | 3.1 ± 0.8 | 3.1 ± 0.8 | 3.0 ± 0.8 |
| HDL (mmol/L) | 1.4 ± 0.4 | 1.4 ± 0.4 | 1.3 ± 0.4 | 1.3 ± 0.4 | 1.3 ± 0.4 |
| Triglycerides (mmol/L) | 1.3 ± 0.8 | 1.4 ± 0.8 | 1.5 ± 0.9 | 1.5 ± 0.8 | 1.5 ± 0.9 |
| Lipid-Lowering Medications (%) | 11 | 14 | 15 | 16 | 18 |
| C-Reactive Protein (nmol/L ) | 21.0 ± 30.5 | 26.7 ± 40.0 | 31.4 ± 40.0 | 37.1 ± 45.7 | 46.7 ± 61.0 |
| IL-6 (IU/mL) | 0.1 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.3 ± 0.2 |
Continuous variables are means ± standard deviations