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. 2016 Apr 29;9:2565–2574. doi: 10.2147/OTT.S100468

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© 2016 Zhang et al. This work is published and licensed by Dove Medical Press Limited

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Upregulation of STMN1 is associated with autophagy enhanced by X-irradiation in A549 and H1299 cells.

Notes: (A) STMN1 was dramatically upregulated in NSCLC cell lines compared to HBE by Western blot method. (B) The protein expression level of STMN1, Beclin1, and LC3II/I was upregulated when A549 and H1299 cells were treated with X-ray irradiation at 2 and 4 Gy compared with 0 Gy control groups measured with Western blot. (C) The protein expression levels of STMN1 in STMN1-up/downregulating of A549 and H1299 cells by Western blot analysis. Data presented as mean ± SD, *P<0.05, **P<0.01, ***P<0.001.

Abbreviations: anti-con, the control of anti-STMN1 loss models; anti-STMN1, STMN1 loss model; con, control; HBE, human bronchial epithelial cells; Lv-NC, the control of gain models; Lv-STMN1, STMN1 gain model; NSCLC, non-small-cell lung cancer; STMN1, Stathmin1; SD, standard deviation.