Table 2.

Intralesional injections

Medication	Mechanism of action	Data supporting	AUA guidelines	Side effects
Intralesional interferon	Decrease fibroblast proliferation	One RCT (multi-institutional), eight observational studies	Recommended when appropriate	Flu-like symptoms, rash, hypotension
Intralesional verapamil	Decrease collagen deposition	RCT, observational	Recommended when appropriate	Bruising, nausea, dizziness
Intralesional collagenase	Cleavage of collagenase	Four RCTs; IMPRESS I, II, observational study	Recommended when appropriate	Hematoma, bruising, corporal rupture

Abbreviation: RCT, randomized controlled trial.