Table 1.

NCI-CTCAE version 4.0 grading scale of skin and subcutaneous tissue disorders

	EGFRis-associated rash
Grade 1	Papules and/or pustules covering <10% of the BSA associated or not associated with symptoms of pruritis or tenderness
Grade 2	Papules and/or pustules covering 10–30% of the BSA associated or not associated with symptoms of pruritis or tenderness; psychosocial impact; limiting instrumental ADL
Grade 3	Papules and/or pustules covering >30% of the BSA associated or not associated with pruritis or tenderness; limiting self-care ADL, associated with local superinfection (oral antibiotics indicated)
Grade 4	Covering any percentage of the BSA associated or not with pruritis or tenderness; associated with severe superinfection (intravenous antibiotics indicated); life-threatening consequences
Grade 5	Death

BSA = Body surface area; ADL = activity of daily living.