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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Neurobiol Aging. 2016 Mar 4;42:41–49. doi: 10.1016/j.neurobiolaging.2016.02.028

Figure 4. Trypsin neuroprotection does not depend on γ-secretase activity.

Figure 4

DAPT, a γ-secretase inhibitor, was added in 7DIV WT neuronal cultures at a concentration of 4 μM, 2 hours before treatment with trypsin. Healthy Hoechst-stained nuclei were counted and paired t-test statistical analysis showed that DAPT does not affect trypsin-mediated neuroprotection. Results (mean ± standard error [SE]) were calculated from 4 independent experiments. *p<0.05, (Tukey’s post hoc). DAPT shows no neurotoxicity