. Author manuscript; available in PMC: 2017 Jan 1.

Published in final edited form as: Transl Res. 2015 Jun 23;167(1):7–34. doi: 10.1016/j.trsl.2015.06.011

Table 2.

Preclinical Studies Demonstrating the Importance of HO-1 in Disease

Strain	Model	Phenotype	Refs

Hmox1−/−	Vascular Injury	Increased intimal hyperplasia	29
	Pulmonary Ischemia/Reperfusion	Repression of fibrinolysis	30
	Hypoxia	Increased myocardial infarction, Right ventricular dilation	31

Hmox1TG (Cardiac)	Ischemia/Reperfusion	Protection from I/R injury	32
Hmox1TG (Cardiac)	Ischemia/Reperfusion	Reduction of cardiomyocyte apoptosis	33
Hmox1TG (Cardiac, Inducible)	Cardiotoxicity (Cre-recombinase)	Protection from cardiotoxicity	34

Hmox1TG (Pulmonary)	Hypoxia-induced pulmonary hypertension	Reduced symptoms of hypertension	35
Hmox1TG (Pulmonary)	Hypoxia-induced pulmonary hypertension	Anti-inflammatory protection	36

Hmox1TG (Keratinocyte)	Skin lesions	Improved wound healing and vascularization	37