Table 3.
The highest‐grade toxicity seen in 470 dogs with appendicular osteosarcoma treated with limb amputation and prescribed carboplatin and doxorubicin‐based chemotherapy protocols.
| Protocol | No Reported Toxicity (%) | Grade (%) | ||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||
| CARBO4 | 35 (37.6) | 37 (39.8) | 17 (18.3) | 1 (1.1) | 3 (3.2) | 0 (0.0) |
| CARBO6 | 47 (51.6) | 29 (31.9) | 9 (9.9) | 3 (3.3) | 3 (3.3) | 0 (0.0) |
| CARBODOX6 | 38 (39.2) | 37 (38.1) | 13 (13.4) | 4 (4.1) | 4 (4.1) | 1 (1.0) |
| DOX5.2 | 30 (24.2) | 48 (38.7) | 34 (27.4) | 7 (5.6) | 5 (4.0) | 0 (0.0) |
| DOX5.3 | 25 (38.5) | 20 (30.8) | 16 (24.6) | 4 (6.2) | 0 (0.0) | 0 (0.0) |