Table 4.
Summary of distribution of first metastatic disease event and treatment for metastatic disease by chemotherapy protocol.
| CARBO 4 | CARBO6 | CARBODOX6 | DOX5.2 | DOX5.3 | |
|---|---|---|---|---|---|
| Number of dogs that developed metastases | 63 (67.7%) | 48 (52.8%) | 66 (68.0%) | 81 (65.3%) | 36 (55.4%) |
| First site of mets/recurrence | |||||
| Lungs | 43 | 35 | 49 | 60 | 30 |
| Bone | 13 | 12 | 5 | 14 | 2 |
| Lungs and bone | 2 | 0 | 7 | 2 | 0 |
| Recurrence | 0 | 0 | 1 | 0 | 0 |
| Othera | 5 | 1 | 4 | 5 | 4 |
| Treatment for metastasesb | |||||
| IV chemo | 9 | 3 | 2 | 1 | 0 |
| Metronomicsc | 7 | 8 | 7 | 0 | 7 |
| IV chemo followed by metronomicsc | 3 | 0 | 0 | 0 | 0 |
| Toceranibd ± metronomic cyclophosphamide | 2 | 8 | 1 | 0 | 0 |
a
Other organs including skin, lymph nodes, abdominal organs.
b
Other than prednisolone or nonsteroidal anti‐inflammatory alone.
c
Metronomic cyclophosphamide and a nonsteroidal anti‐inflammatory.
d
Palladia, Zoetis, Florham Park, NJ.