Figure 2.
Time–activity curves of gallbladder to liver activity ratios [using mean counts per pixel per regions of interest (ROI)] for ABCB1 wild/wild dogs before (○: mean G/L ratio +SD, n = 6) and after (°: mean G/L ratio −SD, n = 6) administration of ketoconazole (5 mg/kg PO q12 h × 9 doses).9 Reproduced from: Coelho JC 1, Tucker R, Mattoon J, Roberts G, Waiting DK, Mealey KL Biliary excretion of technetium‐99 m‐sestamibi in wild‐type dogs and in dogs with intrinsic (ABCB1‐1Delta mutation) and extrinsic (ketoconazole treated) P‐glycoprotein deficiency. J Vet Pharmacol Ther. 2009 Oct;32(5):417–421.