Table 4.
Clinicopathological parameters of the NPI+ BC biological classes in the Edinburgh series
| Luminal A (n = 219) n (%) | Luminal N (n = 144) n (%) | Luminal B (n = 137) n (%) | Basal – p53 altered (n = 90) n (%) | Basal – p53 normal (n = 64) n (%) | HER2+/ER+ (n = 32) n (%) | HER2+/ER− (n = 55) n (%) | Cramer's V (p‐value) | |
|---|---|---|---|---|---|---|---|---|
| Size | ||||||||
| <15 mm | 89 (40.6) | 67 (46.5) | 50 (36.5) | 12 (13.3) | 18 (28.1) | 7 (23.3) | 11 (21.2) | 0.169 (<0.001) |
| ≥15 mm | 130 (59.4) | 77 (53.5) | 87 (63.5) | 78 (86.7) | 46 (71.9) | 23 (76.7) | 41 (78.8) | |
| Grade | ||||||||
| 1 | 75 (33.6) | 47 (30.9) | 35 (25.0) | 1 (1.1) | 3 (4.4) | 3 (9.7) | 1 (1.8) | |
| 2 | 108 (48.4) | 73 (48.0) | 72 (51.4) | 10 (10.8) | 23 (33.8) | 8 (25.8) | 23 (41.8) | 0.381 (<0.001) |
| 3 | 40 (17.9) | 32 (21.1) | 33 (23.6) | 82 (88.2) | 42 (61.8) | 20 (64.5) | 31 (56.4) | |
| Lymph node stage | ||||||||
| 1 | 172 (76.4) | 108 (71.1) | 100 (71.4) | 68 (73.1) | 50 (71.4) | 15 (46.9) | 31 (56.4) | |
| 2 | 44 (19.6) | 40 (26.3) | 36 (25.7) | 18 (19.4) | 18 (25.7) | 10 (31.2) | 15 (27.3) | 0.169 (<0.001) |
| 3 | 9 (4.0) | 4 (2.6) | 4 (2.9) | 7 (7.5) | 2 (2.9) | 7 (21.9) | 9 (16.4) | |
| NPI | ||||||||
| Excellent | 55 (24.8) | 33 (21.9) | 23 (16.4) | 0 | 1 (1.5) | 2 (6.2) | 0 | |
| Good | 82 (36.9) | 54 (35.8) | 53 (37.9) | 5 (5.4) | 15 (22.1) | 5 (15.6) | 11 (20.0) | |
| Moderate 1 | 52 (23.4) | 34 (22.5) | 37 (26.4) | 39 (41.9) | 29 (42.6) | 7 (21.9) | 17 (30.9) | |
| Moderate 2 | 22 (9.9) | 26 (17.2) | 21 (15.0) | 37 (39.8) | 19 (27.9) | 10 (31.2) | 16 (29.1) | 0.221 (<0.001) |
| Poor | 11 (5.0) | 4 (2.6) | 4 (2.9) | 8 (8.6) | 4 (5.9) | 6 (18.8) | 8 (14.5) | |
| Very poor | 0 | 0 | 2 (1.4) | 4 (4.3) | 0 | 2 (6.2) | 3 (5.5) | |
| Adjuvant therapy | ||||||||
| Chemotherapy | 5 (2.2) | 12 (7.9) | 4 (2.9) | 25 (26.9) | 21 (30.0) | 6 (18.8) | 16 (29.1) | |
| Hormone therapy | 185 (82.2) | 100 (65.8) | 112 (80.0) | 42 (45.2) | 32 (45.7) | 19 (59.4) | 26 (47.3) | |
| Hormone therapy/chemotherapy | 14 (6.2) | 21 (13.8) | 11 (7.9) | 10 (10.8) | 6 (8.6) | 4 (12.5) | 6 (10.9) | 0.230 (<0.001) |
| No therapy | 21 (9.3) | 19 (12.5) | 13 (9.3) | 16 (17.2) | 11 (15.7) | 3 (9.4) | 7 (12.7) |