Table 2.

Results of the targeted genetic anlysis for H3F3A and H3F3B and USP6 rearrangment

		Mutation characteristic of tumour
Tumour type	Original Dx (n)	GCT				CB		ABC	WT	aRevised diagnosis (n)
		G34W/A (n)	G34L/A (n)	G34R/A (n)	G34M/A (n)	K36/A (n)	K36/B (n)	USP6 (n)
GCT	91	83	0	1	1	0	0	2	4	89
GCT of small bones	25	14	2	0	0	0	0	3	6	21
CB	7	0	0	0	0	5	2	0	0	7
ABC	44	2	0	0	0	0	1	32	9	41
NOF	66	4	0	0	0	0	0	0	62	62
Tenosynovial giant cell Tumour	51	0	0	0	0	0	0	0	51	51
Osteoblastoma	21	0	0	0	0	0	0	0	21	21
Osteoid osteoma	9	0	0	0	0	0	0	0	9	9
Giant cell granuloma of jaw (solitary)	78	0	0	0	0	0	0	0	78	78
Adamantinoma	8	0	0	0	0	0	0	0	8	8
Osteofibrous dysplasia	6	0	0	0	0	0	0	0	6	6
Total no of mutations		103	2	1	1	5	3	37	252

^aDiagnosis revised following review of histology and imaging on discovery of the genetic alterations