Skip to main content
. Author manuscript; available in PMC: 2017 Apr 13.
Published in final edited form as: J Am Chem Soc. 2016 Mar 30;138(14):4962–4971. doi: 10.1021/jacs.6b02032

Table 3.

Versatility of the reaction conditions using 6 in the HAT hydrogenation.

graphic file with name nihms781737u4.jpg
entry Temp. (°C) conditions conv/yield (%)a d.r.
1 22 0.1 mol%, 1 M 100/92 6.3
2 22 0.1 mol%, 0.25 M 99/97 6.6
3 22 0.1 mol%, 0.1 Mb 100/97 7.6
4 0 1 mol%, 0.5 M 91/91 7.5
5 −30 1 mol%, 0.5 M 96/71 11.3
a

Determined by GC-FID using 1 equiv. of decane as internal standard.

b

Reaction time 13 h.