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Schematic representation of the feline LTBP2 protein in normal (top) and affected cats (bottom). The sequence contains an amino terminal signal sequence (dark rectangle), 13 EGF-like calcium binding domains (green) and 3 TGF binding domains (blue). The insertion site causing a frameshift mutation in affected animals is marked by a vertical bar and the altered sequence caused by the frameshift is indicated by a hatched box.
