Fig 1. Single-molecule sensing with a nanopore device.

(a) Schematic diagram of the setup with voltage V applied across a single nanopore fabricated in a solid-state substrate, while measuring the current through the pore. (b) A representative event caused by a 3.2 kb dsDNA passing through an 27 nm diameter nanopore at V = 100 mV (1M LiCl). Events are quantitated by shift conductance (δG = δI/V) and duration. (c) Scatter plot of δG versus duration for 713 events recorded over 10 minutes.