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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: J Immunol. 2015 Dec 18;196(2):614–623. doi: 10.4049/jimmunol.1500355

Figure 8.

Figure 8

Schematic diagram for ARID3a functions during human hematopoiesis. Degrees of shading represent the proportion of cells initially expressing ARID3a in HSPC subsets HSC, hematopoietic stem cell; MPP, multipotent progenitor, MLP, multi-lymphoid progenitor and MMP, multi-myeloid progenitor. ARID3a inhibition resulted in increased development of myeloid lineage cells (1, thicker arrow) versus lymphocyte lineages, and inhibited B lymphocyte lineage development without affecting natural killer (NK) cells (2). Conversely, ARID3a over-expression blocked myeloid lineage development at unidentified stages resulting in decreased maturation of erythroid (E), monocyte (M), granulocyte/monocyte (GM), granulocyte/erythroid/megakaryocyte/monocyte (GEMM) and erythroid burst blast (BFU-E) colonies (3).