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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: JAMA. 2015 Nov 3;314(17):1850–1860. doi: 10.1001/jama.2015.13134

Figure 7. Asian Elephant Cells and DNA Damage Response.

Figure 7

A, An example is shown of percentage of annexin V–positive (AV+) (apoptotic) lymphocytes from a 17-year-old Asian elephant compared with AV+ lymphocytes from an 18-year-old human 18 hours after ionizing radiation exposure. Error bars represent 95%CIs and significant differences computed with a 2-sided t test are indicated. B, Evidence of p21 protein expression is seen 5 hours after 2 Gy of ionizing radiation in Asian elephant lymphocytes. C, The apoptotic response in Asian elephant lymphocytes is shown to decrease with age (P = .002 by linear regression and P < .001 by Jonckheere-Terpstra tests). A single elephant of each indicated age was tested in triplicate. GAPDH indicates glyceraldehyde 3-phosphate dehydrogenase, a protein-loading control.

aP = .006.

bP < .001.