Table 5.
Association between placental mtDNA content and birth weight (g) in INMA, EVIRONAGE, and in the pooled sample.
| INMAa,b | ENVIRONAGE | INMA + ENVIRONAGEc | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Differences in birth weight (g) (95% CI) | p-Value | Interaction p-value | n | Differences in birth weight (g) (95% CI) | p-Value | Interaction p-value | n | Differences in birth weight (g) (95% CI) | p-Value | Interaction p-value | |
| All | 376 | 249.0 (83.6, 414.3) | 0.003 | 0.003 | 550 | 129.2 (7.8, 259.0) | 0.04 | 0.04 | 926 | 140.2 (43.2, 237.2) | 0.005 | 0.009 |
| Boys | 194 | 124.0 (45.6, 202.5) | 0.002 | NA | 277 | 34.0 (–34.4, 102.4) | 0.33 | NA | 471 | 65.9 (17.9, 114.0) | 0.007 | NA |
| Girls | 182 | –2.44 (–80.5, 75.6) | 0.95 | NA | 273 | –15.2 (–69.3, 39.0) | 0.58 | NA | 455 | 26.4 (–67.4, 14.6) | 0.21 | NA |
| NA, not applicable. Effect size was estimated for each IQR increment (INMA = 0.58; ENVIRONAGE = 0.77; pooled sample = 0.76) in mtDNA content. aModels were adjusted for gestational age (linear and quadratic), newborn’s sex, maternal age, maternal smoking status, prepregnancy BMI, parity, ethnicity, season of birth, education, and interaction term sex and mtDNA content. bFour INMA subcohorts were included as random effect. cCohorts were included as random effect. | ||||||||||||