. 2015 Sep 22;124(5):674–680. doi: 10.1289/ehp.1409472

Table 4.

Associations between OP urinary metabolites and WISC-IV working memory scores (n = 231; PELAGIE cohort, France).

OP metabolites (nmol/L)	n	β (95% CI)
Pregnancy urinary samples
DAP^a
< 22.2	77	Reference
22.2–68.8	77	–1.5 (–5.9, 2.9)
> 68.8	77	–0.6 (–5.0, 3.9)
Log-concentration	231	–0.55 (–1.44, 0.34)
DM^b
< 15.5	77	Reference
15.5–59.9	77	–1.3 (–5.7, 3.1)
> 59.9	77	–0.6 (–5.1, 4.0)
Log-concentration	231	–0.64 (–1.81, 0.53)
DE^c
< LOQ	116	Reference
> LOQ–13.2	58	–0.7 (–5.0, 3.6)
> 13.2	57	2.1 (–2.3, 6.4)
Log-concentration	231	0.13 (–0.29, 0.55)
6-year urinary samples
DAP^a
< 3.95	77	Reference
3.95–25	76	–0.6 (–5.0, 3.7)
> 25	78	–2.6 (–6.9, 1.8)
Log-concentration	231	–0.23 (–1.03, 0.57)
DM^b
< LOD	91	Reference
> LOD–13	70	–0.5 (–4.8, 3.8)
> 13	70	0.2 (–4.1, 4.5)
Log-concentration	231	0.07 (–0.51, 0.64)
DE^c
< LOD	109	Reference
> LOD–11.1	61	–1.5 (–5.7, 2.8)
> 11.1	61	–3.6 (–7.8, –0.6)
Log-concentration	231	–0.33 (–0.76, 0.10)
Abbreviations: DAP, dialkyphosphate; DM, dimethylphosphate; DE, diethylphosphate. Urinary concentrations during pregnancy and during childhood were included simultaneously in the models. Models of natural log–transformed exposure concentrations were run after confirming p > 0.05 for departures from linearity. All models were adjusted for HOME score, breastfeeding duration, mothers’ IQ, school, maternal education level, psychologist testing the child, creatinine levels of mother and child, parity, and season of urine collection. ^aDAP models were also adjusted for maternal alcohol use at inclusion, and disturbances during testing. ^bDM models were also adjusted for maternal alcohol use at inclusion, disturbances during testing, marital status, maternal fruit and vegetable consumption, maternal fish intake, and child’s sex. ^cDE models were also adjusted for marital status, maternal fish intake, and child’s sex.