Table 5.

Associations between OP urinary metabolites and WISC-IV verbal comprehension scores (n = 231; PELAGIE cohort, France).

OP metabolites (nmol/L)	n	β (95% CI)
Pregnancy urinary samples
DAPa
< 22.2	77	Reference
22.2–68.8	77	3.4 (–1.4, 8.1)
> 68.8	77	3.0 (–1.8, 7.8)
Log-concentration	231	0.32 (–0.63, 1.28)
DMb
< 15.5	77	Reference
15.5–59.9	77	0.4 (–4.5, 5.3)
> 59.9	77	1.1 (–3.9, 6.2)
Log-concentration	231	0.37 (–0.93, 1.66)
DEc
< LOQ	116	Reference
> LOQ–13.2	58	–0.7 (–5.4, 4.0)
> 13.2	57	5.5 (0.8, 10.3)
Log-concentration	231	0.33 (–0.12, 0.79)
6-year urinary samples
DAPa
< 3.95	77	Reference
3.95–25	76	1.8 (–3.0, 6.5)
> 25	78	–1.3 (–6.1, 3.5)
Log-concentration	231	–0.45 (–1.32, 0.42)
DMb
< LOD	91	Ref
> LOD–13	70	–0.1 (–4.9, 4.6)
> 13	70	–2.6 (–7.3, 2.1)
Log-concentration	231	–0.33 (–0.96, 0.31)
DEc
< LOD	109	Reference
> LOD–11.1	61	–0.4 (–5.1, 4.2)
> 11.1	61	–0.9 (–5.5, 3.7)
Log-concentration	231	–0.03 (–0.51, 0.44)
Abbreviations: DAP, dialkyphosphate; DM, dimethylphosphate; DE, diethylphosphate. Urinary concentrations during pregnancy and during childhood were included simultaneously in the models. Models of natural log–transformed exposure concentrations were run after confirming p > 0.05 for departures from linearity. All models were adjusted for HOME score, breastfeeding duration, mothers’ IQ, school, maternal education level, psychologist testing the child, and creatinine levels of mother and child. aDAP models were also adjusted for disturbances during testing. bDM models were also adjusted for disturbances during testing, parity, season of urine collection, maternal fruit and vegetable consumption, and child’s sex. cDE models were also adjusted for maternal fish intake.