Table 2.
Accuracy of C. elegans or zebrafish embryogenesis toxicity data for predicting developmental outcomes in rabbits and rats.
| Predicting species | Predicted speciesa | |
|---|---|---|
| Rabbit | Rat | |
| C. elegans | ||
| BA (percent) | 52.3 | 52.7 |
| Sensitivity (percent) | 74.1 | 73.7 |
| Specificity (percent) | 30.4 | 31.7 |
| ZebrafishP | ||
| BA (percent) | 44.6 | 52.2 |
| Sensitivity (percent) | 68.2 | 76.3 |
| Specificity (percent) | 20.9 | 28.0 |
| ZebrafishT | ||
| BA (percent) | 49.6 | 50.6 |
| Sensitivity (percent) | 60.0 | 61.0 |
| Specificity (percent) | 39.1 | 40.2 |
| BA, balanced accuracy = average of sensitivity and specificity. Data were available across all species for 200 unique chemicals. ZebrafishP is from Padilla et al. (2012), and ZebrafishT is from Truong et al. (2014). aThe species listed in each row was used to predict the outcome of the species across columns. | ||