Table 3.
Proportion of chemicals classified as active and concordance between assays among groups of Phase I chemicals.
Chemical classa (number of chemicals) | Proportion activeb | Concordancec | ||||
---|---|---|---|---|---|---|
C. elegans | ZebrafishP | ZebrafishT | C. elegans and ZebrafishP | C. elegans and ZebrafishT | ZebrafishP and ZebrafishT | |
Amide (24) | 0.58 | 0.75 | 0.75 | 0.75 | 0.50 | 0.75 |
Anilide (14) | 0.64 | 0.79 | 0.86 | 0.86 | 0.50 | 0.64 |
Carbamate (15) | 0.53 | 0.80 | 0.67 | 0.60 | 0.73 | 0.73 |
Conazole (18) | 1.00 | 1.00 | 0.89 | 1.00 | 0.89 | 0.89 |
Organophosphate (35) | 0.80 | 0.86 | 0.57 | 0.83 | 0.49 | 0.54 |
Phenoxy (12) | 0.67 | 0.92 | 0.33 | 0.75 | 0.33 | 0.42 |
Pyrethroid (12) | 0.92 | 1.00 | 0.67 | 0.92 | 0.58 | 0.67 |
Pyridine (10) | 0.70 | 0.60 | 0.40 | 0.90 | 0.50 | 0.60 |
Urea (8) | 0.63 | 0.75 | 0.63 | 0.38 | 0.50 | 0.38 |
aChemical classes were derived from Judson et al. (2010). bChemical activity is based on the specific assays for ZebrafishP (Padilla et al. 2012), ZebrafishT (Truong et al. 2014), and C. elegans (this publication). cConcordance is defined as the proportion of chemicals with the same classification. |