Table 4.
Balanced accuracya of C. elegans, ZebrafishP, and ZebrafishT assays for predicting developmental outcomes in rabbits and rats according to chemical class.
Chemical class | Ratsb | Rabbitsb | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
n | Percent active | C. elegans | ZebrafishP | ZebrafishT | n | Percent active | C. elegans | ZebrafishP | ZebrafishT | |
Amide | 21 | 0.48 | 0.62 | 0.63 | 0.54 | 22 | 0.36 | 0.76 | 0.72 | 0.42 |
Anilide | 14 | 0.50 | 0.57 | 0.57 | 0.50 | 14 | 0.43 | 0.81 | 0.69 | 0.33 |
Carbamate | 14 | 0.71 | 0.50 | 0.70 | 0.43 | 14 | 0.50 | 0.64 | 0.71 | 0.71 |
Conazole | 16 | 1.00 | All activec | All activec | 2 inactivec | 16 | 0.69 | 0.50 | 0.50 | 0.41 |
Organophosphate | 25 | 0.32 | 0.43 | 0.53 | 0.36 | 25 | 0.24 | 0.50 | 0.58 | 0.60 |
Phenoxy | 8 | 0.75 | 0.50 | 0.75 | 0.75 | 11 | 0.27 | 0.52 | 0.33 | 0.31 |
Pyrethroid | 12 | 0.50 | 0.42 | 0.50 | 0.33 | 10 | 0.40 | 0.38 | 0.50 | 0.33 |
Pyridine | 7 | 0.43 | 0.63 | 0.75 | 0.42 | 6 | 0.50 | 0.33 | 0.50 | 1.00 |
Urea | 6 | 0.83 | 0.30 | 0.30 | 0.90 | 5 | 0.60 | 0.75 | 0.17 | 0.75 |
aAverage sensitivity and specificity. bData for rats and rabbits were obtained from the ToxRef database (http://www.epa.gov/ncct/toxrefdb/) (Knudsen et al. 2009). cUnable to calculate balanced accuracy because of the absence of sufficient negative results. |