Table 4.

Balanced accuracy^a of C. elegans, Zebrafish^P, and Zebrafish^T assays for predicting developmental outcomes in rabbits and rats according to chemical class.

Chemical class	Ratsb					Rabbitsb
	n	Percent active	C. elegans	ZebrafishP	ZebrafishT	n	Percent active	C. elegans	ZebrafishP	ZebrafishT
Amide	21	0.48	0.62	0.63	0.54	22	0.36	0.76	0.72	0.42
Anilide	14	0.50	0.57	0.57	0.50	14	0.43	0.81	0.69	0.33
Carbamate	14	0.71	0.50	0.70	0.43	14	0.50	0.64	0.71	0.71
Conazole	16	1.00	All activec	All activec	2 inactivec	16	0.69	0.50	0.50	0.41
Organophosphate	25	0.32	0.43	0.53	0.36	25	0.24	0.50	0.58	0.60
Phenoxy	8	0.75	0.50	0.75	0.75	11	0.27	0.52	0.33	0.31
Pyrethroid	12	0.50	0.42	0.50	0.33	10	0.40	0.38	0.50	0.33
Pyridine	7	0.43	0.63	0.75	0.42	6	0.50	0.33	0.50	1.00
Urea	6	0.83	0.30	0.30	0.90	5	0.60	0.75	0.17	0.75
aAverage sensitivity and specificity. bData for rats and rabbits were obtained from the ToxRef database (http://www.epa.gov/ncct/toxrefdb/) (Knudsen et al. 2009). cUnable to calculate balanced accuracy because of the absence of sufficient negative results.