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. 2015 Oct 23;124(5):586–593. doi: 10.1289/ehp.1409645

Table 4.

Balanced accuracya of C. elegans, ZebrafishP, and ZebrafishT assays for predicting developmental outcomes in rabbits and rats according to chemical class.

Chemical class Ratsb Rabbitsb
n Percent active C. elegans ZebrafishP ZebrafishT n Percent active C. elegans ZebrafishP ZebrafishT
Amide 21 0.48 0.62 0.63 0.54 22 0.36 0.76 0.72 0.42
Anilide 14 0.50 0.57 0.57 0.50 14 0.43 0.81 0.69 0.33
Carbamate 14 0.71 0.50 0.70 0.43 14 0.50 0.64 0.71 0.71
Conazole 16 1.00 All activec All activec 2 inactivec 16 0.69 0.50 0.50 0.41
Organophosphate 25 0.32 0.43 0.53 0.36 25 0.24 0.50 0.58 0.60
Phenoxy 8 0.75 0.50 0.75 0.75 11 0.27 0.52 0.33 0.31
Pyrethroid 12 0.50 0.42 0.50 0.33 10 0.40 0.38 0.50 0.33
Pyridine 7 0.43 0.63 0.75 0.42 6 0.50 0.33 0.50 1.00
Urea 6 0.83 0.30 0.30 0.90 5 0.60 0.75 0.17 0.75
aAverage sensitivity and specificity. bData for rats and rabbits were obtained from the ToxRef database (http://www.epa.gov/ncct/toxrefdb/) (Knudsen et al. 2009). cUnable to calculate balanced accuracy because of the absence of sufficient negative results.
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