Table 1. The shape presentation parameters of all TVs in different week (mean ± SD, 95% CI).
| Parameters | TV | Week |
Mean | |||||
|---|---|---|---|---|---|---|---|---|
| 1st | 2nd | 3rd | 4th | 5th | 6th | |||
| OI_pCT | GTV_T | 0.81±0.09 (0.77, 0.86) | 0.71±0.12 (0.65, 0.76) | 0.61±0.15 (0.55, 0.68) | 0.55±0.16 (0.48, 0.63) | 0.48±0.15 (0.41, 0.56) | 0.43±0.15 (0.36, 0.51) | 0.60±0.19 (0.57, 0.64)* |
| GTV_Nl | 0.71±0.23 (0.51, 0.90) | 0.59±0.24 (0.39, 0.79) | 0.47±0.26 (0.25, 0.68) | 0.41±0.24 (0.21, 0.68) | 0.35±0.23 (0.16, 0.54) | 0.32±0.21 (0.14, 0.49) | 0.47±0.26 (0.40, 0.55)* | |
| GTV_Ns | 0.62±0.18 (0.54, 0.69) | 0.49±0.16 (0.43, 0.56) | 0.38±0.17 (0.31, 0.45) | 0.31±0.16 (0.25, 0.38) | 0.29±0.15 (0.23, 0.35) | 0.25±0.16 (0.18, 0.32) | 0.39±0.20 (0.36, 0.42)* | |
| CTV_Lr | 0.93±0.04 (0.91, 0.95) | 0.92±0.04 (0.91, 0.94) | 0.90±0.04 (0.88, 0.92) | 0.89±0.05 (0.87, 0.91) | 0.87±0.04 (0.85, 0.89) | 0.86±0.04 (0.84, 0.88) | 0.90±0.05 (0.89, 0.91)* | |
| OI_rCT | GTV_T | 0.98±0.02 (0.97, 0.99) | 0.97±0.02 (0.96, 0.98) | 0.97±0.03 (0.95, 0.98) | 0.96±0.03 (0.95, 0.98) | 0.96±0.03 (0.95, 0.98) | 0.96±0.04 (0.94, 0.98) | 0.97±0.03 (0.96, 0.97) |
| GTV_Nl | 0.96±0.03 (0.94, 0.98) | 0.95±0.03 (0.92, 0.98) | 0.93±0.06 (0.88, 0.99) | 0.93±0.07 (0.87, 0.99) | 0.93±0.08 (0.86, 1.00) | 0.92±0.08 (0.99, 0.85) | 0.94±0.06 (0.92, 0.96) | |
| GTV_Ns | 0.86±0.11 (0.82, 0.91) | 0.84±0.12 (0.79, 0.89) | 0.80±0.21 (0.71, 0.88) | 0.78±0.22 (0.69, 0.88) | 0.77±0.20 (0.69, 0.85) | 0.74±0.27 (0.62, 0.85) | 0.80±0.20 (0.77, 0.86) | |
| CTV_Lr | 0.95±0.03 (0.94, 0.96) | 0.95±0.02 (0.94, 0.96) | 0.95±0.02 (0.93, 0.95) | 0.94±0.02 (0.93, 0.95) | 0.94±0.03 (0.92, 0.95) | 0.93±0.03 (0.92, 0.95) | 0.94±0.03 (0.94, 0.95)* | |
| DSC† | GTV_T | 0.89±0.06 (0.86, 0.91) | 0.81±0.09 (0.77, 0.85) | 0.74±0.11 (0.69, 0.79) | 0.69±0.13 (0.63, 0.75) | 0.63±0.14 (0.56, 0.70) | 0.58±0.14 (0.52, 0.65) | 0.72±0.15 (0.70, 0.75)* |
| GTV_Nl | 0.79±0.17 (0.65, 0.93) | 0.70±0.20 (0.54, 0.87) | 0.59±0.24 (0.39, 0.79) | 0.54±0.23 (0.35, 0.73) | 0.48±0.23 (0.29, 0.67) | 0.44±0.22 (0.26, 0.63) | 0.59±0.24 (0.52, 0.66)* | |
| GTV_Ns | 0.70±0.15 (0.64, 0.77) | 0.61±0.14 (0.55, 0.66) | 0.50±0.18 (0.42. 0.57) | 0.43±0.18 (0.36, 0.50) | 0.41±0.18 (0.33, 0.48) | 0.36±0.20 (0.27, 0.54) | 0.50±0.21 (0.44, 0.54)* | |
| CTV_Lr | 0.94±0.03 (0.93, 0.96) | 0.94±0.02 (0.93, 0.95) | 0.92±0.03 (0.91, 0.94) | 0.91±0.03 (0.90, 0.93) | 0.90±0.03 (0.89, 0.92) | 0.89±0.03 (0.88, 0.91) | 0.92±0.03 (0.91, 0.92)* | |
| Mean SPD† (mm) | GTV_T | 1.5±0.8 (1.1, 1.8) | 2.4±1.2 (1.9, 3.0) | 3.3±1.6 (2.6, 4.0) | 4.2±2.1 (3.2, 5.2) | 5.0±2.3 (4.0, 6.1) | 5.8±2.5 (4.6, 7.0) | 3.7±2.3 (3.3, 4.1)* |
| GTV_Nl | 2.3±2.0 (0.6, 4.0) | 3.4±2.2 (1.5, 5.2) | 4.8±2.6 (2.6, 6.9) | 5.3±2.5 (3.7, 7.4) | 5.9±2.4 (3.8, 7.9) | 6.3±2.4 (4.3, 8.3) | 4.6±2.6 (3.9, 5.4)* | |
| GTV_Ns | 1.9±1.1 (1.5, 2.4) | 2.6±1.0 (2.2, 3.1) | 3.4±1.2 (2.9, 3.8) | 3.9±1.3 (3.4, 4.4) | 4.2±1.6 (3.5, 4.9) | 5.2±3.5 (3.7, 6.7) | 3.5±2.1 (3.2, 3.9)* | |
| CTV_Lr | 1.0±0.5 (0.8, 1.3) | 1.1±0.5 (0.9, 1.3) | 1.4±0.5 (1.1, 1.6) | 1.6±0.6 (1.3, 1.9) | 1.7±0.6 (1.4, 2.0) | 1.9±0.6 (1.6, 2.2) | 1.4±0.6 (1.3, 1.6)* | |
| Overall SD† (mm) | GTV_T | 2.2±1.2 (1.7, 2.8) | 3.0±1.2 (2.4, 3.6) | 3.5±1.5 (2.8, 4.2) | 4.1±1.9 (3.2, 5.0) | 4.7±1.9 (3.8, 5.6) | 5.2±2.4 (4.1, 6.3) | 3.7±2.3 (3.3, 4.1)* |
| GTV_Nl | 2.1±1.2 (1.1, 3.1) | 2.7±1.1 (1.8, 3.6) | 3.6±1.3 (2.5, 4.8) | 3.7±1.2 (2.7, 4.7) | 3.9±1.2 (2.8, 4.9) | 3.9±1.2 (2.9, 4.9) | 3.3±1.3 (2.9, 3.7)* | |
| GTV_Ns | 1.8±0.8 (1.9, 2.6) | 2.2±0.7 (1.9, 2.6) | 2.6±0.9 (2.3, 3.0) | 2.9±0.9 (2.6, 3.3) | 3.2±1.3 (2.6, 3.7) | 4.0±3.2 (2.7, 5.4) | 2.8±1.7 (2.5, 3.1)* | |
| CTV_Lr | 2.1±0.8 (1.7, 2.5) | 2.1±0.7 (1.8, 2.4) | 2.4±0.7 (2.1, 2.7) | 2.6±0.8 (2.2, 3.0) | 2.8±0.8 (2.4, 3.1) | 3.0±0.9 (2.6, 3.4) | 2.5±0.8 (2.4, 2.7)* | |
OI of the initial volume on pCT calculated by TV_common/TV_pCT (OI_pCT) or TV_common/TV_rCT (OI_rCT); TV_pCT, TV_rCT, and TV_common are the initial volume on the planning CT, the volume delineated manually on repeat CTs, and their common volumes, respectively. †, the OI and DSC was calculated as 2× TV_common/(TV_rCT + TV_pCT). And mean SPD is the mean surface distances between TVs in rCT and its pCT. Overall SD was calculated as the SD of all the SPDs from each point in the surface of TV delineated in rCT image; *, P value <0.05 when comparing among different weeks with one-way analysis of variance. TV, target volume; SD, standard deviation; 95% CI, 95% confidence interval; GTV_T, GTV of the primary tumor; GTV_Nl, GTV of a large lymph node; CTV_Nl, CTV of a large lymph node (the shortest diameter >3.0 cm); GTV_Ns, GTV of a small lymph node (>1 cm and ≤3 cm); CTV_Lr, CTV of a low risk region; CRT, chemoradiotherapy; SPD, the shortest perpendicular distance; OI, overlapping index; DSC, dice similarity coefficient; GTV, gross tumor volume; CTV, clinical target volume.