Table 1.
Demographic, anthropometric, clinical, laboratory, and kidney function parameters and concomitant medications at baseline according to randomization to sirolimus added on to conventional therapy (sirolimus) or conventional therapy only (conventional)
| Patients Parameters and Medications | Sirolimus, n=21 | Conventional, n=20 |
|---|---|---|
| Age, yr | 49.0 (7.1) | 47.6 (8.1) |
| Men, no. (%) | 9 (42.9) | 8 (40.0) |
| Height, cm | 168.7 (10.1) | 168.5 (10.3) |
| Weight, kg | 73.5 (14.3) | 73.8 (17.8) |
| BP, mmHg | ||
| Systolic | 136.3 (10.6) | 133.8 (14.4) |
| Diastolic | 86.1 (7.7) | 85.5 (8.4) |
| Mean | 102.8 (7.8) | 101.6 (9.8) |
| Laboratory parameters | ||
| AST, U/L | 18.5 (3.5) | 19.4 (5.1) |
| ALT, U/L | 16.7 (4.6) | 16.4 (4.9) |
| GGT, U/L | 24.0 (14.9) | 22.2 (9.7) |
| Alkaline phosphatase, U/L | 66.2 (14.4) | 58.5 (18.5) |
| Calcium, mg/dl | 9.3 (0.3) | 9.2 (0.5) |
| Phosphorus, mg/dl | 4.0 (0.5) | 3.7 (0.4) |
| Sodium, mEq/L | 139.9 (1.8) | 140.0 (1.6) |
| Potassium, mEq/L | 4.3 (0.4) | 4.1 (0.6) |
| Blood glucose, mg/dl | 89.8 (11.4) | 88.4 (12.2) |
| Uric acid, mg/dl | 6.6 (1.3) | 7.1 (1.5) |
| Total cholesterol, mg/dl | 201.7 (27.6) | 203.9 (25.7) |
| LDL cholesterol, mg/dl | 125.3 (23.9) | 127.5 (32.4) |
| HDL cholesterol, mg/dl | 47.5 (10.3) | 51.8 (14.3) |
| Triglycerides, mg/dl | 120.4 (37.2) | 105.8 (45.6) |
| Leukocytes, ×103/μl | 5.7 (1.5) | 5.6 (1.8) |
| Hemoglobin, g/dl | 12.3 (1.6) | 12.4 (1.2) |
| Hematocrit, % | 37.1 (5.0) | 37.5 (3.5) |
| Platelets, ×103/μl | 194.2 (56.4) | 188.1 (46.6) |
| Kidney function parameters | ||
| Serum creatinine, mg/dl | 2.89 (0.62) | 2.52 (0.49) |
| GFR, ml/min per 1.73 m2 | 26.8 (5.6) | 30.8 (6.6) |
| Albuminuria, μg/min | 43.0 (23.8–84.1) | 53.4 (42.8–131.7) |
| Proteinuria, g/24 h | 0.25 (0.16–0.36) | 0.24 (0.15–0.45) |
| Concomitant medications, no. (%) | ||
| ACE inhibitors | 12 (57.1) | 11 (55.0) |
| ARBs | 7 (33.3) | 8 (40.0) |
| CCBs | 9 (42.9) | 5 (25.0) |
| α-Blocking agents | 2 (9.5) | 6 (30.0) |
| β-Blockers | 7 (33.3) | 3 (15.0) |
| Diuretics | 6 (28.6) | 5 (25.0) |
| Statins | 2 (9.5) | 3 (15.0) |
| Anticoagulants | 0 (–) | 2 (10.0) |
| Iron | 1 (4.8) | 1 (5.0) |
| ESAs | 3 (14.3) | 1 (5.0) |
| Calcium | 1 (4.8) | 1 (5.0) |
| Vitamin D | 5 (23.8) | 6 (30.0) |
| Bicarbonate | 2 (9.5) | 2 (10.0) |
| PPIs | 3 (14.3) | 3 (15.0) |
Values are mean (SD), median (interquartile range), or number (percentage). GFR was by the iohexol plasma clearance technique. Mean BP = (systolic BP +2× diastolic BP)/3. AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ-glutamyl-transpeptidase; ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker; CCB, calcium channel blocker; ESA, erythropoiesis-stimulating agent; PPI, proton pump inhibitor.