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. 2016 Feb 22;11(5):785–794. doi: 10.2215/CJN.09900915

Table 3.

Renal function parameters at baseline and the end of the 1-year treatment period according to randomization to sirolimus added on to conventional therapy (sirolimus) or conventional therapy only (conventional)

Sirolimus Conventional
Renal Function Parameters Baseline, n=16 1 yr, n=16 Baseline, n=17 1 yr, n=17
Diuresis, ml/24 h 2268.8 (648.3) 2245.6 (851.2) 2287.7 (560.4) 2508.4 (639.8)
Serum creatinine, mg/dl 3.02 (0.59) 4.03 (1.03)a 2.63 (0.45) 3.35 (0.83)a
GFR, ml/min per 1.73 m2 26.7 (5.8) 21.3 (6.3)a 29.6 (5.6) 24.9 (6.2)b
Albuminuria, μg/min 46.3 (26.0–80.9) 101.7 (50.5–194.6)b 53.7 (48.3–120.9) 69.5 (33.6–103.1)a,c
Proteinuria, g/24 h 0.28 (0.17–0.37) 0.49 (0.39–0.70)a 0.27 (0.15–0.45) 0.29 (0.17–0.44)d

Data are means (SDs) or medians (interquartile ranges). GFR was measured by the iohexol plasma clearance technique.

a

P<0.01 versus baseline (paired t test).

b

P<0.05 versus baseline (paired t test).

c

P<0.05 versus sirolimus adjusted for baseline value (analysis of covariance).

d

P<0.01 versus sirolimus adjusted for baseline value (analysis of covariance).