Table 3.
Sirolimus | Conventional | |||
---|---|---|---|---|
Renal Function Parameters | Baseline, n=16 | 1 yr, n=16 | Baseline, n=17 | 1 yr, n=17 |
Diuresis, ml/24 h | 2268.8 (648.3) | 2245.6 (851.2) | 2287.7 (560.4) | 2508.4 (639.8) |
Serum creatinine, mg/dl | 3.02 (0.59) | 4.03 (1.03)a | 2.63 (0.45) | 3.35 (0.83)a |
GFR, ml/min per 1.73 m2 | 26.7 (5.8) | 21.3 (6.3)a | 29.6 (5.6) | 24.9 (6.2)b |
Albuminuria, μg/min | 46.3 (26.0–80.9) | 101.7 (50.5–194.6)b | 53.7 (48.3–120.9) | 69.5 (33.6–103.1)a,c |
Proteinuria, g/24 h | 0.28 (0.17–0.37) | 0.49 (0.39–0.70)a | 0.27 (0.15–0.45) | 0.29 (0.17–0.44)d |
Data are means (SDs) or medians (interquartile ranges). GFR was measured by the iohexol plasma clearance technique.
P<0.01 versus baseline (paired t test).
P<0.05 versus baseline (paired t test).
P<0.05 versus sirolimus adjusted for baseline value (analysis of covariance).
P<0.01 versus sirolimus adjusted for baseline value (analysis of covariance).