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. 2016 May 6;4:40. doi: 10.3389/fcell.2016.00040

Figure 1.

Figure 1

p38 implication in osteoblast differentiation. Osteoblast differentiation is characterized by the expression of a specific cohort of proteins depicted in the lower panel. p38 is related both to differentiation and proliferation of bone progenitors. p38-mediated phosphorylation promotes progression in osteogenesis by the enhancement of the activity or expression of osteoblast-specific transcription factors genes. Direct arrows indicate direct phosphorylation while dashed arrow indicates indirect action of p38. Phosphorylated residues are specified for every target.