Figure 1.

Crystal Structure of the Puumala Gn Ectodomain

(A) A ribbon representation of Puumala (PUUV) Gn colored from blue (N terminus) to red (C terminus). N-linked glycans are shown as green sticks.

(B) Domain schematic of PUUV glycoprotein precursor with the signal peptide (SP), ectodomain, transmembrane domain (TM), intravirion domain (IV), zinc finger (ZF), and WAASA signal peptidase cleavage site shown (produced with DOG; Ren et al., 2009). Y-shaped symbols designate N-linked glycosylation sites. The location of the additional putative N-linked glycosylation site at Asn235 in Hantaan virus (Lys243 in PUUV) is indicated in gray.

See also Figures S1 and S2.