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. 2016 Apr 21;15(5):1088–1099. doi: 10.1016/j.celrep.2016.04.005

Figure 1.

Figure 1

Homozygous NKG2C Deletion Is Associated with Accumulation of Terminally Differentiated Effector Memory CD45RA+ T Cells

(A and B) Frequency of EMRA CD8 T cells in HCMV+NKG2C+ donors (A) and HCMV+NKG2C−/− donors (B) plotted against the age of the donor.

(C) Frequency of EMRA CD8 T cells in donors <50 and >50 years old as a function of NKG2C deletion.

(D) Frequency of IFN-γ+ CD8 T cells after overnight stimulation with pp65 overlapping peptide pools.

(E) Frequency of HCMV-specific CD8 T cells as defined by HLA-A∗02 or HLA-B∗07 tetramers refolded with pp65-derived peptides. Gray lines represent the median value within each group.