Figure 3.

MicroPET imaging of IR and SS animals with the tracers [18F]WC-4-116 and [18F]ICMT-18. (A) Structure of [18F]WC-4-116. (B) Structure of [18F]ICMT-18. (C-F) Representative late summed microPET images of IR and SS animals imaged with [18F]WC-4-116 (C, D) or [18F]ICMT-18 (E, F). [18F]WC-4-116 microPET imaging demonstrates LV tracer uptake in IR (panel C) but not SS animals (D). Images of IR (E) and SS (F) animals administered [18F]ICMT-18 demonstrate no focal myocardial accumulation of this tracer. White boxes denote cardiac position; white arrowhead indicates LV uptake.