Table 3.
Location and comparison of LEP SNPs in whole cohort and participants with DNA methylation
| SNP | Genotype | Coordinate | Location | Whole cohort (n%) | Subpopulation with DNA-M data (n%) | p-value |
|---|---|---|---|---|---|---|
| rs10249476 | TT | 127877026 | Flanking | 147 (13.47) | 49 (14.2) | 0.16 |
| AC | 5’UTR | 512 (47.93) | 177 (51.3) | |||
| CC | 432 (39.60) | 119 (34.5) | ||||
| rs11763517 | TT | 127890062 | Intron | 277 (25.3) | 76 (21.9) | 0.26 |
| CT | 542 (49.6) | 179 (51.6) | ||||
| CC | 274 (25.1) | 92 (26.5) | ||||
| rs4731429 | TT | 127903539 | Flanking | 224 (20.51) | 76 (22.09) | 0.44 |
| CT | 3’UTR | 550 (50.37) | 174 (50.58) | |||
| CC | 318 (29.12) | 94 (27.33) | ||||
| rs10954176 | TT | 127907319 | Flanking | 319 (29.4) | 93 (27) | 0.43 |
| CT | 3’UTR | 508 (46.8) | 164 (48) | |||
| CC | 258 (23.8) | 86 (25.1) |