Table 8.
*Effect of the interaction term of the CpG site and SNP on FEV1, FEV1/FVC, FEF25-75%, and asthma at age 18, stratified by atopy in IOW cohort
| Outcome | Genotype | Atopic individuals (n=239) | Non-atopic individuals (n=126) | ||
|---|---|---|---|---|---|
|
| |||||
| Estimate (S.E.) | p-value | Estimate (S.E.) | p-value | ||
| FEV1 | |||||
| rs11763517 | CT | 1.61 (0.74) | 0.033 | 1.19 (0.51) | 0.02 |
| CC+TT | Ref. | Ref. | Ref. | Ref. | |
| cg00666422 | 2.14 (1.12) | 0.06 | 1.95 (0.79) | 0.015 | |
| cg00666422*rs11763517 | CT | -3.86 (1.58) | 0.02 | -2.65 (1.13) | 0.019 |
| CC+TT | Ref. | Ref. | Ref. | Ref. | |
| FEV1/FVC | |||||
| rs11763517 | CT | 0.17 (0.12) | 0.18 | 2.28 (0.08) | 0.0008 |
| CC+TT | Ref. | Ref. | |||
| cg00666422 | 0.27 (0.19) | 0.15 | 0.38 (0.13) | 0.0029 | |
| cg00666422*rs11763517 | CT | -0.39 (0.26) | 0.14 | -0.63 (0.18) | 0.0006 |
| CC+TT | Ref. | Ref. | |||
| FEF25-75% | |||||
| rs11763517 | CT | 2.99 (1.69) | 0.08 | 4.12 (1.08) | 0.0002 |
| CC+TT | Ref. | Ref. | Ref. | Ref. | |
| cg00666422 | 4.51 (2.55) | 0.08 | 6.17 (1.68) | 0.0003 | |
| cg00666422*rs11763517 | CT | -7.18 (3.59) | 0.05 | -9.14 (2.39) | 0.0002 |
| CC+TT | Ref. | Ref. | Ref. | Ref. | |
| Asthma at age 18 | |||||
| cg00666422 | -3.25 (4.77) | 0.50 | -8.27 (4.03) | 0.04 | |
| rs11763517 | CT | -1.94 (2.82) | 0.49 | -10.30 (4.80) | 0.03 |
| rs11763517 | CC+TT | Ref. | Ref. | Ref. | Ref. |
| cg00666422*rs11763517 | CT | 5.08 (6.02) | 0.40 | 20.68 (10.06) | 0.04 |
| CC+TT | Ref. | Ref. | Ref. | Ref. | |