Table 10.
Interaction effect of LEP CpG and SNP on FEV1, and FEV1/FVC in both boys and girls at 8 years of age in BAMSE cohort
| Parameter | Genotype | Estimate | Standard Error | p-value |
|---|---|---|---|---|
| FEV1 | ||||
| rs11763517 | CT | 0.321 | 0.1926 | 0.0967 |
| CT+TT | Ref. | Ref. | ||
| cg00666422 | -0.2451 | 0.2491 | 0.3257 | |
| cg00666422*rs11763517 | CT | 0.4786 | 0.4911 | 0.3305 |
| CC+TT | Ref. | Ref. | ||
| FEV1/FVC | ||||
| rs11763517 | CT | 0.000482 | 0.00601 | 0.93701 |
| CT+TT | Ref. | Ref. | ||
| cg00666422 | -0.00235 | 0.00785 | 0.76486 | |
| cg00666422*rs11763517 | CT | -0.09062 | 0.1555 | 0.56056 |
| CC+TT | Ref. | Ref. |
*Adjusted for maternal asthma, paternal asthma, maternal smoking, height, and weight at age 8, and weighted for sex.