Table 2.
GNAS and KRAS findings in colorectal tumors
| Tubular adenoma | Tubulovillous adenoma | Villous adenoma | Carcinoma with residual adenoma | Carcinom | P value | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Benign | Malignant | ||||||
|
|
|||||||
| No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | No. (%) | ||
| No. | 25 | 31 | 98 | 62 | 86 | ||
| GNAS | |||||||
| Mutated | 0 (0) | 2 (6.4) | 11+ (11.2) | 6+ (9.7) | 3 (4.8) | 0 (0) | 0.53 |
| Wild | 25 (100) | 29 (93.6) | 87 (88.8) | 56 (90.3) | 59 (95.2) | 86 (100) | |
| GNAS Mutation type | |||||||
| R201H | 2 | 7 | 5 | 2 | |||
| R201C | 5 | 1 | 1 | ||||
| R201S | 1 | ||||||
| KRAS | |||||||
| Mutated | 4 (16) | 22 (71) | 60 (61) | 33 (53) | 39 (63) | 27 (31) | <0.0001 |
| Wild | 21 (84) | 9 (29) | 38 (39) | 29 (47) | 23 (37) | 59 (69) | |
+
One tumor had two different mutations.