Table 2.
Dynamics of clinical parameters in patients with chronic hepatitis B during LdT treatment
| Parameters | Baseline | 3 mo | 6 mo | 9 mo | 13 mo |
| HBV DNA load (log10 IU/mL) | 8.41 (7.68-8.80) | 3.79a (3.20-5.14) | 3.04a (2.48-3.98) | 2.81a (2.48-3.10) | 2.48a (2.48-3.50) |
| ALT level (U/L) | 117.35 (74.50-241.48) | 36.00a (23.93-85.50) | 27.00a (22.00-38.00) | 27.50a (23.00-34.25) | 29.50a (24.00-55.00) |
| AST level (U/L) | 96.75 (57.25-176.25) | 34.00a (28.00-55.25) | 26.00a (22.00-31.25) | 24.50a (19.75-30.00) | 27.00a (22.75-43.25) |
| HBsAg level (IU/mL) | 7821.43 (3337.23-20737.14) | 4214.99a (2034.48-10170.46) | 5153.19a (2039.45-10671.30) | 4414.88a (2317.96-10084.21) | 4210.48a (1664.73-9823.78) |
Data are represented as median and interquartile range (IQR). Normal values: ALT ≤ 50 IU/L; AST ≤ 40 IU/L; HBV DNA ≤ 1.78 log10 IU/mL (60 IU/mL).
a
P < 0.05 vs baseline value. The undetectable HBV DNA loads were recorded as those ≤ 60 IU/mL. CHB: Chronic hepatitis B; HBV: Hepatitis B virus; ALT: Alanine transferase; AST: Aspartate transferase; HBsAg: Hepatitis B surface antigen.