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. 2016 May 6;6:25511. doi: 10.1038/srep25511

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Copyright © 2016, Macmillan Publishers Limited

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(A) Comparison between polytene chromosomes of wild-type Oregon-R (left panel) and w, elav-GAL4^[w+]/w; UAS-Cfdp1^[w+]/+ (right panel) larvae stained with DAPI. Chromosome structure is highly disorganised in larvae expressing UAS-Cfdp1. Chromosome morphology was strongly affect in 231/350 (66%) figures scored were scored from three different replicates of the same cross. (B) Polytene chromosomes of UAS-Cfdp1^[w+]/UAS-Cfdp1^[w+] larvae which do not express CFDP1 protein stained with DAPI (left panels); multiple H2A.V signals are present (right panel); (C) Polytene chromosomes of w, elav-GAL4^[w+]/w; UAS-Cfdp1^[w+]/+ larvae (left panel); H2A.V protein levels are decreased (right panel); (D) Polytene chromosomes of UAS-Cfdp1^[w+]/UAS-Cfdp1^[w+] larvae stained with DAPI (left panels); multiple H2A signals are present (right panel); (E) Polytene chromosomes of w, elav-GAL4^[w+]/w; UAS-Cfdp1^[w+]/+ larvae (left panel); H2A protein levels are decreased (right panel); (F) Polytene chromosomes of w, elav-GAL4^[w+]/w; UAS-Cfdp1^[w+]/+ larvae stained with DAPI (left panel); strong staining with anti-CFDP1 antibody (right panel); in this case chromosome morphology is not dramatically affected.