Table 2. Pharmacokinetic profile in vaginal lavage.
| Parameters | Units | EFV* |
Curcumin# |
||
|---|---|---|---|---|---|
| ECNPs | Sol (EFV + Cur) | ECNPs | Sol (EFV + Cur) | ||
| AUC | (h)*(mg/ml) | 20.4164 | 13.7581 | 32.4251 | 21.9066 |
| AUMC | (h)^2*(mg/ml) | 132.482 | 52.448 | 172.922 | 56.496 |
| Cmax | mg/mL | 4.9126 | 4.2897 | 9.7794 | 8.9723 |
| Tmax | hr | 2 | 1 | 2 | 1 |
| t1/2 | hr | 4.63222 | 2.14916 | 3.97347 | 1.8513 |
Pharmacokinetic parameters.
AUC: The integral of the concentration-time curve (after a single dose or in steady state).
AUMC: Partial area under the moment curve between t start and t end.
Cmax: The peak plasma concentration of a drug after oral administration.
Tmax: Time to reach Cmax.
t1/2: The time required for the concentration of the drug to reach half of its original value.
*EFV credentials measured individually when delivered via ECNPs and Sol (EFV+Cur) respectively.
#Cur credentials measured individually when delivered via ECNPs and Sol (EFV+Cur) respectively.