Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 May 5;7:11473. doi: 10.1038/ncomms11473

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Binding of HAdV-D43 and -D53 E3/49K proteins (100 nM) to wt (right) EPHA3-transfected (left) cells visualized by immunofluorescence. (b) Actin cytoskeleton and tyrosine phosphorylation changes upon stimulation with ephrin-A5, the viral proteins indicated or the combination of both. Assay shown is representative of two independent experiments. (c) Effects on adhesion of HEK293T cells to FN-coated plates. The cells were mock-treated or pre-incubated with the indicated viral proteins (100 nM), stimulated with Ephrin-A5 and incubated on FN-coated plates. Plots represents one assay run in quadruplicates out of two independent experiments. HAdV-D43 E3/49K protein counteracts ephrin-A5 effect on cell adhesion (Students t-test, (P<0.0001). Mean±s.d. is represented in all cases. Scale bars, 20 μm.