Figure 7.

TRX-1 regulates SKN-1 nuclear localization cell non-autonomously. TRX-1 expressed in the ASJ neurons negatively controls nuclear localization of intestinal SKN-1, independently of its redox activity, probably through an unknown signaling intermediate. Two possible models by which ASJ-localized TRX-1 could cell non-autonomously direct SKN-1 nuclear localization in the intestine are shown. (1) A novel modification of SKN-1 could occur that results in p38 MAPK pathway-dependent nuclear localization of SKN-1, but not activation. (2) An alteration in signaling through the p38 MAPK pathway activity could cause SKN-1 localization without concurrent transcriptional activation.